Assessment of T-cell responses in most low resource settings is typically performed using the ELISpot assay.14 The ELISpot assay quantifies cells producing IFN-γ, a sole type II interferon primarily produced by primed CD4+ and CD8+ T-cells; these are primary subsets, critical for evaluating SARS-CoV-2-specific T cell immune responses following vaccination and/or infection.11 But also, a small cell population such as NK- and NK T cells could secrete IFN-γ and contribute to the spot formation. Here, IFNG is linked to infection.