The multilineage differentiation ability of iPSCs also provides a model platform for the study of AD (Figure 3); this platform can be used not only to evaluate potential drugs for the treatment of AD but also to simulate the interaction between nerve cells in vivo for studying the cascade reaction caused by Aβ plaques and hyperphosphorylated tau in patients with AD [100, 101]. This evidence concerns the gene MAPT and Alzheimer disease.