STX2 and Thrombocytopenia: Due to the absence of the Stx2 receptor Gb3 in mouse glomerular endothelial cells (Psotka et al., 2009; Porubsky et al., 2014), OMV-treated mice did not develop Stx2-mediated glomerular endothelial damage and the associated glomerular TMA (Figures 5C, G), thrombocytopenia, and hemolytic anemia (Figures 6E–J), which are hallmarks of EHEC-HUS in humans (Tarr et al., 2005), who possess Gb3 on the glomerular endothelium (Obrig, 2010; Porubsky et al., 2014; Legros et al., 2017).