EHEC O157 OMV-associated LPS and flagellin induce secretion of interleukin-8 from human intestinal epithelial cells (Bielaszewska et al., 2018), which may also contribute to the pathogenesis of EHEC-HUS (Zoja et al., 2010). This evidence concerns the gene CXCL8 and hemolytic-uremic syndrome.