Porubsky and colleagues demonstrated, using transgenic mice lacking Gb3 in tubular epithelial cells, that the tubular absence of Gb3 protected mice against Stx2-mediated tubular injury, acute kidney failure, and death observed in wild-type mice that carried Gb3 on tubular epithelial cells (Porubsky et al., 2014). This evidence concerns the gene STX2 and acute kidney injury.