As shown in Figure 7 and Table S8, induction with STZ, resulted in a significant reduction in mRNA levels for PI3K, AKT, INSR, and GLUT‐2 by 1.68‐, 1.62‐, 1.84‐, and 1.85‐fold, respectively, indicating that STZ may induce T2DM through the downregulation of these mRNA expressions in rats (p < 0.01). This evidence concerns the gene AKT1 and type 2 diabetes mellitus.