IFNG and congenital rubella syndrome: However, like hematotoxicity, CRS and ICANS were associated with elevated baseline proinflammatory markers, including IL‐1β, IL‐1α, TNF‐α, and IFN‐γ, further supporting the role of a proinflammatory state as a shared pathophysiological feature across CAR‐T‐related toxicities (Figure S3B).