HAVCR2 and B-cell chronic lymphocytic leukemia: However, CD8+ CAR T cells from CLL patients continued to express significantly higher levels of TIM‐3+LAG‐3+ than their ALL counterparts after 4 days of co‐culture (mean difference in P: −21.4% ± 5.5; in C: −18.1% ± 5.5, P < 0.05).