Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon, and slows gastric emptying, making it highly effective for weight loss and type 2 diabetes management [3-5]. Here, GLP1R is linked to type 2 diabetes mellitus.