Subsequently, multivariate ordinal regression analysis revealed that AST (OR = 1.614 (1.589, 1.639), P < 0.001), ALP (OR = 1.005 (1.003, 1.0080, P < 0.001), LDL-C (OR = 1.043 (0.977, 1.114), P = 0.208), HDL-C (OR = 1.177 (0.953, 1.454), P = 0.129), and RC (OR = 1.336 (1.163, 1.537), P < 0.001) exacerbated the progression of NAFLD (Table 1, Figure 2), while ALT (OR = 0.815 (0.808, 0.82), P < 0.001), γ-GGT (OR = 0.999 (0.997, 1.000), P < 0.001), platelet (OR = 0.919 (0.918.0.922), P < 0.001), and TyG (OR = 0.436 (0.224, 0.848), P < 0.014) can inhibit its progression (Table 1; Figure 2). This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.