In addition, we used available Olink proteomic data to characterise enriched pathways and upstream regulators of proteins associated with <i>ADRB2</i> polymorphisms.<h4>Results</h4>The minor T allele of Thr164Ile was associated with reduced lung function, but not COPD or asthma or risk of exacerbations on long-acting β-agonist treatment. This evidence concerns the gene ADRB2 and chronic obstructive pulmonary disease.