Currently, only a subset of genes, including HNF1A, GCK, HNF4A, HNF1B, PDX1, NEUROD1, INS, ABCC8, and KCNJ11 are considered to have definitive or strong evidence supporting their causative role in MODY, while APPL1 has only limited evidence. This evidence concerns the gene APPL1 and MODY.