EMT is considered a key factor in tumor invasion and metastasis [47], and it is characterized by the absence of epithelial cell markers (e.g. cytokeratins and E-cadherin) and upregulation of the expression of mesenchymal cell markers (e.g. N-cadherin, Vimentin and Snail, Twist) [48]. Here, CDH1 is linked to neoplasm.