Transcription Factor Binding to IGHM Enhancer 3-rearranged renal cell carcinoma (TFE3-rRCC) is a distinct subtype of renal cell carcinoma that predominantly affects young and middle-aged patients and is characterized by chromosome translocations involving the Transcription Factor E3 (TFE3) gene (HGNC:11752) (Pinto and Chetty, 2020). This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.