Functional validation using CRISPR excision of candidate regions revealed that expression of placental genes: CSF1R (colony stimulating factor 1 receptor; promotes growth, proliferation, and migration of trophoblast), PSG5 (pregnancy specific glycoprotein 5, specifically expressed by STB and EVT), and ENG (endoglin; contributes to and is marker of preeclampsia) is controlled by the neighboring LTR elements acting as enhancers (LTR10A, LTR8B, and MER41B, respectively). This evidence concerns the gene PSG5 and preeclampsia.