YAP1 and central nervous system cancer: Among other signaling pathways, ROS levels were shown to activate Drosophila Yorkie or its mammalian ortholog YAP1 (Yes-associated protein 1) in Drosophila enterocytes and human glioma cell lines (Dixit et al., 2014; Nagai et al., 2021), a molecule which has been shown to be directly upregulating tissue proliferation (Milton et al., 2014; Snigdha et al., 2019).