This mini-review was based on a targeted literature search conducted in PubMed/MEDLINE and Scopus from January 2015 to August 2025, using the keywords “GLP-1 receptor agonists,” “exercise,” “physical activity,” “obesity,” “type 2 diabetes,” and “weight loss.” Additional terms (“lean mass,” “body composition,” “insulin sensitivity,” “cardiometabolic,” “combined intervention”) were used in secondary searches. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.