More strikingly, the number of people without diabetes in which we could detect S‐specific CD4+ T cells at the time point examined was significantly higher than that of T1D participants (25 out of 44 ND and 14 out of 44 T1D, p = 0.031), while the T2D group showed a comparable number of participants harboring S‐specific CD4+ T cells as ND (Figure 1C). Here, CD4 is linked to type 2 diabetes mellitus.