Unsupervised clustering analysis identified 11 different clusters of S‐specific CD4+ T cells (Figure 1I; Figure S2), and the distribution of cells within such clusters did not vary significantly between ND and participants with diabetes (Figure 1J), with only people with T2D displaying a modest decrease in the frequency of cells in Cluster 1 and a significant increase in the frequency of cells in clusters 9 and 11 compared with ND (Figure S3; Table S2). This evidence concerns the gene CD4 and diabetes mellitus.