CD4 and type 1 diabetes mellitus: In addition, and similarly to the CD4+ T cell compartment, the frequency of individuals in whom S‐specific CD8+ T cells could be detected was significantly lower in T1D compared with ND controls (22 out of 44 ND and 10 out of 44 T1D participants, p = 0.0142), while no differences were observed between T2D and ND (Figure 2C).