The MVMR results supported that CTSS was causally responsible for DLBCL (ORIVW = 1.204, 95% CI 1.042–1.392, P = .012; ORMR-Egger = 1.200, 95% CI 1.038–1.387, P = .014). The gene discussed is CTSS; the disease is diffuse large B-cell lymphoma.