CTSS and diffuse large B-cell lymphoma: Both multivariate IVW and MR-Egger methods supported that elevated CTSS level is a potential hazard factor for patients with DLBCL (Fig. 4A and B, ORIVW = 1.204, 95% CI 1.042–1.392, P = .012; ORMR-Egger = 1.200, 95% CI 1.038–1.387, P = .014).