ESR1 and insomnia: From these results, it is evident that these targets may affect insomnia through inflammation and immune responses (TNF, CXCL8, PTGS2, etc); signal transduction (AKT1, epidermal growth factor receptor [EGFR], STAT3, etc); apoptosis (BCL2, CASP3, etc); metabolism (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], albumin [ALB], PPARG, etc); stress response (HIF1A, HSP90AA1, HSP90AB1, etc); and other (ESR1, APP, etc) physiological processes.