EGFR and insomnia: For comparison, the reported binding energy range of commonly used insomnia drugs, such as zolpidem with the GABA_A receptor, is approximately − 7.0 to − 9.0 kcal/mol.[74] Notably, some SGML-4 components exhibit binding energies to EGFR that are comparable or slightly stronger, highlighting that luteolin, apigenin, and piplartine (with their direct neuromodulatory effects) possess a solid molecular basis as potential EGFR ligands most relevant to insomnia.