Additionally, patients treated with azathioprine showed a reduction in the occurrence of oral ulcers, genital ulcers, and episodes of arthritis.[65] Anti-TNF therapies, including infliximab and adalimumab, have also been effective in managing severe and resistant manifestations of Behçet’s disease, with similar efficacy observed among different TNF inhibitors.[66]. This evidence concerns the gene TNF and arthritic joint disease.