ACE and Hypertension: Prior to sequencing, data were collected uniformly by the research team, which included the subject’s name, age, gender, ethnicity, smoking history, comorbidities (coronary artery disease, hypertension, diabetes mellitus), medication history (angiotensin-converting enzyme inhibitor [ACEI]/angiotensin II receptor blocker [ARB], beta-blockers, calcium antagonists, statins), and biochemical indices (triglycerides, total cholesterol, white blood cell count, lymphocyte count).