The PTPN11 gene is situated on human chromosome 12q24.1, encoding the SHP2 protein (Src Homology 2 Domain-Containing Phosphatase 2), which possesses multiple functional domains, including SH2 and PTPase domains.[6] Through its regulation of RAS/MAPK, PI3K/AKT, and other signaling cascades, SHP2 exhibits a dual function in controlling cell proliferation/differentiation and remodeling the tumor microenvironment.[7] Numerous studies report abnormal PTPN11 expression or mutations in diverse cancers. The gene discussed is PTPN11; the disease is cancer.