PTPN11 and cancer: This study is based on public datasets of PTC to conduct prognostic-related research on PTPN11 in PTC and various cancers, perform immune infiltration and drug sensitivity analyses, and obtain prognostic genes through univariate and least absolute shrinkage and selection operator (LASSO) algorithms, constructing and validating prognostic risk models, functional enrichment analyses, etc. Single-cell transcriptomic analysis is further integrated, with the aim of furnishing a novel theoretical basis and innovative methodologies for the prognosis and treatment of PTC in clinical settings.