Previous studies have found that in mouse models, the use of VX-11e alone can inhibit tumor tissue growth, when combined with the PI3K inhibitor BKM120, it can significantly inhibit tumor growth.[44] Irinotecan is a chemotherapy drug commonly used to treat colorectal cancer and colon cancer, blocking cancer cell growth and proliferation by inhibiting the activity of DNA topoisomerase I.[44] Dactinomycin is an anticancer drug commonly used to treat various malignant tumors.[45] The results suggest that these drugs may have the opportunity to be applied to PTC patients. Here, TOP1 is linked to colorectal cancer.