SHP2 facilitates the proliferation, migration, and invasion of breast cancer cells through the activation of the RAS/ERK signaling pathway, and it is associated with the maintenance and self-renewal capabilities of tumor stem cells.[7] The mechanism of PTPN11 in PTC is not yet fully understood, and no studies have constructed PTPN11-related prognostic models in PTC. The gene discussed is PTPN11; the disease is breast cancer.