Additionally, conditions such as acute myeloid leukemia (AML) with RUNX1::RUNX1T1 fusion, AML with CBFB::MYH11 fusion, myeloid/lymphoid neoplasms with eosinophilia and specific gene rearrangements, and the blast phase of chronic myeloid leukemia (CML) must be excluded from the diagnosis. The gene discussed is CBFB; the disease is Increased total eosinophil count.