Additionally, conditions such as acute myeloid leukemia (AML) with RUNX1::RUNX1T1 fusion, AML with CBFB::MYH11 fusion, myeloid/lymphoid neoplasms with eosinophilia and specific gene rearrangements, and the blast phase of chronic myeloid leukemia (CML) must be excluded from the diagnosis. This evidence concerns the gene RUNX1 and acute myeloid leukemia.