In patients with stage I–III CRC who underwent curative surgical resection, an neutrophil–lymphocyte ratio >2.72 was independently predictive of overall survival.[8] Low serum calcium levels have also been associated with postoperative outcomes in CRC patients.[9] Additionally, the prognostic significance of combining platelet-albumin ratios and cancer inflammation index, and early prediction of anastomotic leakage via nutritional and inflammation-related biomarkers, further emphasize the clinical relevance of patients’ immune-inflammatory and nutritional status.[10,11]. The gene discussed is ALB; the disease is colorectal carcinoma.