The AE whose onset time shorter than 100 days such as dysphagia, NMS, depressed level of consciousness, hypotonia, blood creatine phosphokinase increased, cardiac failure, cardio-respiratory arrest, disseminated intravascular coagulation, hematocrit decreased, hepatic failure, hepatotoxicity, hyponatremia, inappropriate antidiuretic hormone secretion, renal impairment, respiratory failure, salivary hypersecretion. The gene discussed is AVP; the disease is Hepatic failure.