For instance, a prospective cohort study by Ma et al involving 288 patients with chronic hepatitis C demonstrated SII as an independent predictor of liver fibrosis progression.[36] Similarly, a multicenter investigation revealed that heightened SII portends poorer survival outcomes in HCC patients, further validating its prognostic utility.[37] Current biomarkers for systemic inflammation include C-reactive protein, erythrocyte sedimentation rate, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. This evidence concerns the gene CRP and Hepatic fibrosis.