It exerts anti-tumor effects by modulating the immune system and inhibiting angiogenesis.[40,41] Ma et al[42] revealed through a retrospective study that OS patients with higher preoperative platelet-to-albumin ratio and apolipoprotein B-to-A1 ratio had significantly shorter overall survival, indicating that APOA1 is a protective factor in OS, consistent with the findings of this study. This evidence concerns the gene APOB and neoplasm.