Previous studies have identified the roles of cytotoxic T cells (CD8+) and helper T cells (Th, CD4+) in hypertension.[17,18] Th1, Th2, and Th17 cells can promote IFN-γ, the expression of inflammatory factors such as IL-17 and IL-22 leads to the occurrence of hypertension, and regulatory T cells can alleviate the occurrence of hypertension through IL-10 mediated functions.[19]. This evidence concerns the gene CD8A and hypertensive disorder.