RHOA and hypertensive disorder: T cell-derived cytokines play a central role in the pathophysiology of cardiovascular disease and hypertension, leading to terminal organ damage.[20–22] One of the earliest discovered cytokines associated with hypertension is IL-17, which increases blood pressure and reduces NO dependent diastolic response by activating RhoA/Rho kinases.[23] We found that the expression level of IL-17 mRNA in lymphocytes increased in Kazakh hypertensive patients, and serum IL-17 levels also increased compared to the control group.