Other clearly defined adaptive immune cytokines in hypertension include IFN-γ and TNF-α in our study,[25–27] IFN-γ MRNA levels in lymphocytes and IFN in serum-γ the levels are all upregulated in the hypertensive group, and activated lymphocytes promote the expression and release of inflammatory factors during the formation of hypertension, which may be directly related to terminal organ damage in hypertension. This evidence concerns the gene IFNA1 and hypertensive disorder.