MTOR and cancer: This finding aligns with previous studies that have demonstrated the oncogenic potential of the PI3K/Akt/mTOR pathway in cancer progression, emphasizing the need for targeted therapeutic strategies that can inhibit this pathway to improve patient outcomes.[39,40] Furthermore, our functional enrichment analysis revealed that ACTR3 is involved in several critical biological processes, including cilia organization and microtubule movement, which are essential for maintaining cellular architecture and function.