This finding aligns with previous studies that have demonstrated the oncogenic potential of the PI3K/Akt/mTOR pathway in cancer progression, emphasizing the need for targeted therapeutic strategies that can inhibit this pathway to improve patient outcomes.[39,40] Furthermore, our functional enrichment analysis revealed that ACTR3 is involved in several critical biological processes, including cilia organization and microtubule movement, which are essential for maintaining cellular architecture and function. Here, PIK3CA is linked to cancer.