PIK3CA and cervical squamous cell carcinoma: The PI3K/Akt/mTOR signaling pathway is a critical regulator of cellular processes, including growth, proliferation, and survival, and its dysregulation is implicated in various malignancies, including CESC.[4,5] Our study identified significant associations between the expression of key genes within this pathway and patient prognosis, particularly highlighting the role of ACTR3, ARF1, and PDK1.