The PI3K/Akt/mTOR signaling pathway is a critical regulator of cellular processes, including growth, proliferation, and survival, and its dysregulation is implicated in various malignancies, including CESC.[4,5] Our study identified significant associations between the expression of key genes within this pathway and patient prognosis, particularly highlighting the role of ACTR3, ARF1, and PDK1. Here, ACTR3 is linked to cervical squamous cell carcinoma.