Wan et al found the TyG index to be a slightly better marker than homeostasis model assessment in predicting metabolic syndrome.[19] Guerrero-Romero et al further demonstrated that TyG index had high sensitivity and specificity to recognize IR, suggesting that it could be useful for the identification of patients with decreased insulin sensitivity.[20] Besides from IR, this contemporary index has been shown to independently predict increased risk of atherosclerotic CVD even in individuals without established disease. Here, INS is linked to metabolic syndrome.