Critically ill patients often develop stress hyperglycemia due to causes such as trauma, shock, and infection, or experience hypoglycemia following insulin therapy.[1] Studies show that the incidence of stress hyperglycemia in critically ill patients ranges between 30% and 80%.[2] Stress hyperglycemia can lead to increased catabolism, poor wound healing, infections, and other complications. The gene discussed is INS; the disease is Hypoglycemia.