SLC5A2 and acute kidney injury: However, these agents induce an initial, reversible glomerular filtration rate reduction,[24] prompting current guidelines to contraindicate their initiation during acute illness, including AMI, due to acute kidney injury (AKI) risk.[25] Therefore, this study aims to systematically review and conduct a meta-analysis of the existing literature to evaluate the impact of preoperative SGLT2 inhibitors use on cardiorenal outcomes in AMI patients and explore its potential for improving prognosis.