Finally, consistent with the important role of immune cells in the observed tumor suppression from EHMT2 inhibition and TGF-β1 inhibition in immunocompetent mice, treatment with either BRD4770 (Fig. 8H,I) or vactosertib (Fig. 8J,K) failed to inhibit tumor growth in immunodeficient NSG mice. This evidence concerns the gene TGFB1 and neoplasm.