CAR T cells demonstrated significantly better tumour growth control over 96 h compared with non-transduced cells (effector-to-target ratio, 1:5, cytokine-expressing and enriched SK-N-AS neuroblastoma cells after AAVS1 locus knock-in co-cultured with L1CAM-targeting CAR T cells; Fig. 5d). The gene discussed is L1CAM; the disease is neuroblastoma.