To further assess the in vivo relevance of tumour-intrinsic CXCL10 expression under immune-competent conditions, we employed humanized NOG (HuNOG) mice engrafted with human CD34+ haematopoietic stem cells and subsequently xenografted with SK-N-BE2c neuroblastoma cells with or without CXCL10 knock-in at the CHD1 locus. Here, CD34 is linked to neoplasm.