ACE and Allergy: A total of 89 different drugs were detected; the most frequently detected pharmacologic classes included histamine-1 receptor antagonist (allergy), angiotensin II-receptor blocker (cardiology), ACE inhibitor (cardiology), beta-adrenergic receptor inhibitor (cardiology), statin (lipid-lowering), non-steroidal anti-inflammatory drug (NSAID; analgesics), and selective serotonin reuptake inhibitor (SSRI; antidepressant), which matches the most commonly prescribed drug classes in these regions (Fig. 1g)52–54.