Using conventional markers for terminally exhausted (LY108−TIM3+) versus progenitor exhausted (LY108+TIM3−) cells4, the majority of PD1+ CD8+ TILs in B16 tumours from DR-fed mice were progenitor exhausted or an intermediate phenotype (LY108+TIM3+) (Fig. 3h). This evidence concerns the gene CD8A and neoplasm.