Similar to CD8+ TIL from DR-fed mice, OT-I T cells responding to LmOVA infection under DR-fed conditions displayed increased effector function when analysed ex vivo, characterized by an increase in the percentage of IFNγ-producing T cells (Extended Data Fig. 5b), higher IFNγ production on a per-cell basis (Extended Data Fig. 5c) and an increased percentage of GZMB+ CD8+ Teff cells (Extended Data Fig. 5d). Here, CD8A is linked to infection.