Using three spatially-enriched marker genes for each tumor subregion (CT: BCAN, CSPG5, TOP2A; Pseudo: HILPDA, IGFBP5, LGALS3; and MVP: MGP, LUM, THBS1) we identified distinct sub-populations of malignant cells from the scRNA-seq data (Fig. 3C-E). This evidence concerns the gene MGP and neoplasm.