In order to further explore the functional roles of these two hub genes in PDGF-induced PASMCs, we knocked down the COX6B1 and HMGCL in transcriptional level to evaluate if silencing COX6B1 or HMGCL inhibited mitochondrial oxidative stress of PASMCs in PAH. This evidence concerns the gene HMGCL and pulmonary arterial hypertension.