For instance, Abdel-Sattar et al., 2020 demonstrated that NIC attenuated oxidative damage in a CCl4-induced liver fibrosis model by reducing MDA, enhancing GSH and SOD activities, and downregulating NOX expression—effects attributed to activation of the AMPK/SIRT-1 signaling pathway27. The gene discussed is SOD1; the disease is Hepatic fibrosis.