Treatment with NIC at a dose of 7.5 mg/kg led to a 33.25% reduction in TNF-α protein expression, a 41.42% reduction in iNOS protein expression, and a 30.24% decrease in NF-κB-p65 gene expression, while P53 gene expression increased by 50.04% compared to the TAA-induced liver fibrosis group. The gene discussed is TP53; the disease is Hepatic fibrosis.