Consistent with our murine skin single-cell data, we identified two major clusters of keratinocytes in healthy and vitiligo skin; ‘HF’ characterized by high expression of hair follicle-associated markers KRT14 and KRT15, and ‘Epithelia’ that expressed the interfollicular epidermal transcript KRT5. We next applied the PPARγ scoring module to assess the level of activity across the captured cell populations22. Here, KRT15 is linked to hydrops fetalis.