Overexpression of TGFA causes an alteration of gastric lineage cell commitment towards pit cells, and aberrant TGFA/EGFR signaling is also associated with the development of a rare hypertrophic disorder, Ménétrier’s disease, characterized by massive foveolar hyperplasia [12, 16, 17]. The gene discussed is TGFA; the disease is gastric mucosal hypertrophy.