PLXDC2 and metastatic malignant neoplasm in the lymph nodes: In the tumor (T), lymph node (N), and metastasis to distant organs (M) classification, serum PLXDC2 levels tended to increase in the presence of lymph node metastasis (N1‐2) (mean: 32.19 ng/mL) compared to the absence of lymph node metastasis (N0) (mean: 22.24 ng/mL) (p = 0.09) (Figure 2C).