In a fluid‐resuscitated, antibiotic‐treated mouse model of prolonged sepsis, we first (Study 1) assessed the safety and effectiveness (impact on ketosis and muscle weakness) of the PPARα agonist pemafibrate (1 mg/kg/d, n = 16), versus placebo (n = 15) combined with standard balanced parenteral nutrition (PN), composed of glucose, amino acids and long‐chain triglycerides (LCT) (balanced‐TPN). Here, PPARA is linked to Sepsis.