In the present experiment, we performed in silico guided synthesis of 5,5-dimethyl-2-((2-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenylamino)methylene) cyclohexane-1,3-dione (Ph-triazole) to explore its pharmacological abilities against therapeutic targets involved in pancreatic cancer, particularly P53 and TP53. This evidence concerns the gene TP53 and pancreatic neoplasm.