The KEGG enrichment revealed that the main pathways activated are neurotrophin signaling pathway, apoptosis, proteoglycans in cancer, FoxO signaling pathway, ErbB pathway, etc. Differential expression analysis of the most prominent hub gene TP53 in the case of pancreatic cancer showed different pattern of expression as well as prognostic implications. This evidence concerns the gene TP53 and familial pancreatic carcinoma.