In vivo validation, 708 breast tumors tissue microarray (TMA) analysis indicated that SDC1 protein expression in tumor cells was linked to overall survival in breast cancer patients (HR:1.54 (1.01, 2.35), P = 0.04), after adjusting for factors such as age, menopausal status, tumor characteristics, nodal involvement, TNM stage, vascular invasion, chemotherapy, and radiotherapy. Here, SDC1 is linked to breast carcinoma.