SDC1 and neoplasm: We further assessed the relationship of SDC1 expression (in overall tumor tissue, tumor cells, and stromal cells) with patient OS and EFS using multivariable Cox regression, adjusting for clinical variables including age, tumor characteristics, nodal status, menopausal status, radiotherapy, chemotherapy, vascular invasion, and TNM stage. The results demonstrated that high SDC1 expression in tumor cells was an independent prognostic factor associated with worse OS [HR: 1.54 (95% CI 1.01–2.35), P = 0.044] and EFS [HR: 1.80 (95% CI 1.29–2.53), P = 0.001] (Fig. 7).