Concordant with the prior study [12, 13], the depleted lymphoma microenvironment (LME-DP) subtype seemed to be more in patients with DHL/THL (36.4% in DHL-BCL6, 69.2% in DHL, and 66.7% in THL), which was characterized by a minimal presence of immune cells, as well as higher proportions of proliferating tumor cells and presented the worst prognosis (Fig. S6b-c). The gene discussed is BCL6; the disease is lymphoma.