Correspondingly, osteocalcin has been linked to various organ systems and circulating osteocalcin has been associated with negative outcomes in humans such as falls-related hospitalization [9], muscle function [7, 8, 32], fracture [5, 6, 33], osteoporosis [4], osteosarcopenia [10, 34, 35] and mortality [11, 36, 37]. This evidence concerns the gene BGLAP and osteoporosis.