As we previously demonstrated, mice bearing 67NR nonmetastatic mammary tumors exhibited increased trabecular bone mass from day 11 to day 35 after implantation, characterized by decreased OC numbers, enhanced OB lineage cells, and an antiosteoclastogenic immune environment enriched in IFN-γ, IL-10, and regulatory CD8+ T cells (30). This evidence concerns the gene CD8A and breast cancer.