Importantly, the inverse correlation between RANKL expression and tumor purity (ρ = −0.267, P = 3.49e−04) supports the hypothesis that RANKL expression is primarily of immune rather than tumor origin, reinforcing its role in shaping the immunologic microenvironment of BRCA-Basal tumors (Fig. 8A). Here, TNFSF11 is linked to neoplasm.