Concurrently, iron dysregulation in glaucoma drives RGC ferroptosis via nuclear receptor coactivator 4 (NCOA4)-mediated ferritin degradation, resulting in excessive ferrous iron accumulation, heightened oxidative stress, lipid peroxidation, and neurodegeneration, culminating in the hallmark progressive loss of RGCs.28 The gene discussed is NCOA4; the disease is glaucoma.