IFNA1 and infection: Given that the dimerization of IRF3 upon phosphorylation by TBK1 and subsequent nuclear translocation is crucial for IFN gene expression through the IFN-inducing signaling pathway, we investigated the regulatory role of SVCV-P in IRF3 nuclear translocation under conditions of SVCV infection and overexpression of SVCV-P in EPC cells.