In BRCA, the leading Canonical pathway hits are Constitutive Signaling by Aberrant PI3K in Cancer, PI3K AKT Signaling in Cancer, and multiple ERBB4-driven routes, reflecting the centrality of PI3K/AKT and ERBB networks in hormone receptor–positive breast tumors [45, 46]. This evidence concerns the gene NR4A1 and breast neoplasm.